We all know that noxplode is a great pre workout supp but did you know that caffeine is metabolized chiefly by liver enzyme CYP-1A2 and is a pretty strong inhibitor of it. CYP-1A2 and is unfortunately also the chief metabolic enzyme for estradiol. CYP-3A4 is the chief metabolic enzyme for testosterone.So can to much preworkout supps cause puffy nipples and gyno or even inhibit muscle growth?Any one had any issues or puffy nips?