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O.N.

Member
A New Journey Begins!
For over a year now Wicked Supplements has been in back and forth consultation and testing with several pharmaceutical giants. Yes that may sounds strange. How does our company get a foot in the door with these people?

Well really it just came down to knowing the right people for a very long time and allowing us to be fast tracked through the chain of command of different subsidiary companies of the major companies and of course.....money.
Many discussions, in depth thought, 100's of back and forth testing and especially funds have gone into this project for the future of this system.

We have had the privilege to work along side many great minds from the USA, Europe and Australia. To create a highly bio available self emulsifying drug delivery system (SEDDS).

Absorption & Delivery
The key problems faced with almost every dietary ingredient or drug is absorption they will all degrade to some degree during digestion and some will struggle to deliver enough active ingredient to cause the desired results, this is exactly where a SEDDS can be used.

SEDDS (self emulsifying drug delivery systems) are the absolute way of the future!
There are several key components to a SEDDS. I wont go into too much detail but basically we and several pharmaceutical scientists started with what info we had previously obtained from several other drug and supplement formulations and then worked backwards, we went over the what, the hows and the whys? on each and every component. We have conducted countless numbers of tests to validate data.

We have found evidence of a drug currently sold which shows detailed information through minor modifications to different aspects of the SEDDS formula to be able to begin with a starting point of an 1100% increase in delivery versus a powdered tablet and then to further enhance this system to be 1150% and then with even further tweaks end up with a final SEDDS formulation at a 1200% increase in delivery vs powdered tablet. That is for a current drug used in the medical industry right now. Information like this shows us how small modifications in the right areas of a SEDDS are possible to keep pushing delivery percentages higher and higher.

The End Result
After all this planning, consulting, testing, spending thousands of dollars and hundreds of hours we have a SEDDS formula. It certainly works and far exceeds what we thought was possible.....whats the percentage increase?....the answer is 500-800% increase of poorly soluble ingredients and 1000+% of highly soluble ingredients.

How a SEDDS work
The simplest way to understand it would be an entrapment of the active ingredients in the SEDDS. The stomach cannot break down the actives as they are protected in the SEDDS and you can achieve a delivery of your actives intact and ready for absorption.

Once in the digestive tract the SEDDS sticks to the digestive walls and starts forcing the active ingredients into the walls at higher concentrations than normal powdered form, allowing for massive increases in the percentage of delivery.

What About The Taste?
Some of you may remember that bitter after taste from previous SEDDS formulas that has been altered to be much more tolerable with the help of some great people which have helped to flavor many different oral medications currently sold in today's market.

When do i expect this to be ready? 1-2 months but when it's out watch out it will literally deliver!

If you have any questions please ask away
 

Jungnaut

YOLO Kunce
Will this make my Craze preworkout twice as powerful, in less than half the time? If so, I'm in!

And how does SEDD perform when it comes to potentiating recreationals? :eek:
 

O.N.

Member
Will this make my Craze preworkout twice as powerful, in less than half the time? If so, I'm in!

And how does SEDD perform when it comes to potentiating recreationals? :eek:

We have had some pre workout testing last week on 3 users taking different pre workout supplements simply taken in conjunction with the SEDDS, all 3 reported the pre workout kicked in faster, it lasted much longer and was also a lot stronger in action, 2 of the 3 reported that they normally have a buzz for a couple of hours, however it lasted much longer 2 of them claimed they were unable to sleep normally falling asleep around 11pm but not able to get off to sleep until 6-7am the next day.

This was not dissolved into the SEDDS it was simply taken at the same time, showing how efficient the SEDDS is in terms of action, we really wanted to use something like a pre workout where the effects are felt very easily.

All 3 people took their normal doses that they used and compared the results to what they normally feel. 2 guys were using scivation psycho and the 3rd was using an old tub of craze that he had.
 

High Road

New member
All 3 people took their normal doses that they used and compared the results to what they normally feel. 2 guys were using scivation psycho and the 3rd was using an old tub of craze that he had.

Is this the only sort of "scientific" testing you are doing? Do you have any actual evidence to support your claims?
 
S

Stiffy

Guest
The End Result
After all this planning, consulting, testing, spending thousands of dollars and hundreds of hours we have a SEDDS formula. It certainly works and far exceeds what we thought was possible.....whats the percentage increase?....the answer is 500-800% increase of poorly soluble ingredients and 1000+% of highly soluble ingredients.

If you have any questions please ask away

Last week it was Big Mick's thread .........


500-800% increase of poorly soluble ingredients and 1000+% of highly soluble ingredients. This sounds abit too good to be true O.N.?

Whats this gonna cost?

Gotta love your persistence. Hands up chin down O.N. :)
 

lkt004

Member
What did you test the SEDDS on in order to determine the increase in adsorption, it would have to be an animal/cell culture, likely out of reach due to cost for a small supplement company.
 

O.N.

Member
Is this the only sort of "scientific" testing you are doing? Do you have any actual evidence to support your claims?

We looked into the efficiency of oral absorption of several drug compounds with the SEDDS formula. It all depends on many related parameters, such as surfactant concentration, oil/surfactant ratio, droplet size and charge, polarity of the emulsion, all of which will determine the self emulsification ability. Only very specific pharmaceutical excipient combinations will lead to efficient self emulsifying drug delivery systems.

Being able to work with the scientists we were able to examine in depth 4 current SEDDS medications, how and why they worked the way they do.

We were also able to look at a lot of previous study data others have completed with different drugs and supplements from Progesterone to CoQ10 and even tocotrienols. From this study data being able to compare about 20 different formulas gave the ability to see how and where improvements were seen.

For instance a study from the drug Ontazolast it is an asthmatic drug with 4 different variations to the SEDDS formulation we can see an improvement of 800%, 1100%, 1300% and 1500% and you can see the AUC improve also from AUC0-8 hr = 528±68 h ng/mL to AUC0-8 hr =1003±270 h ng/mL

As you can see being able to see so many different formulations is a huge advantage.

We have completed an 18 person trial for toxicology safety data which ran for 30 days comprised of before, during and after blood tests mapping parameters such as liver function, blood pressure etc all persons passed with no issues at all and everybody also completed self reporting daily for anything from headaches to upset stomachs, diarrhea, nausea etc again there were no issues in all 18 participants.

We are very proud of this although the study group is small in scale a great deal of time was spent in getting everything perfect, this is one of the reasons it has taken over a year and I have not said one word about this on the internet until now. This was certainly not a case of quick lets rush things and make a product to start selling.

Last week it was Big Mick's thread .........


500-800% increase of poorly soluble ingredients and 1000+% of highly soluble ingredients. This sounds abit too good to be true O.N.?

Whats this gonna cost?

Gotta love your persistence. Hands up chin down O.N. :)
On this page you can see several comparisons of different SEDDS and their increase in delivery versus powdered tablet note; one of the highest increases was 1500% http://wickedsupplements.com/wp-content/uploads/2014/04/Research-J.-Pharm.-and-Tech.jpg

What did you test the SEDDS on in order to determine the increase in adsorption, it would have to be an animal/cell culture, likely out of reach due to cost for a small supplement company.

As said above we have estimated the percentage increase based on surfactant concentration, oil/surfactant ratio, droplet size and charge, polarity of the emulsion in comparison to others SEDDS formulations.

This is not a case of "we have similar ratios of surfactants" it is a case of what is our droplet size in comparison, what is the charge and polarity how can we modify it to better suit our application. (The smaller the droplet size the more efficient the formulation) Just like micronization of powders have higher absorption rates than powders which have larger particle sizes.

We had regular consultations with 3 pharmaceutical formulators, 2 of which work for a major company based in the USA and Australia (As much as you would like to know which companies all parties have a confidentiality agreement) However we can say they were involved from day 1 and to the present day. Our final test batch from last week was completed by our contract manufacturer and is now being sent to one of the pharmaceutical formulators to make sure everything is perfect before being put into full scale production.

System explained:
The system works no differently to how a regular tablet is consumed and delivered in the digestive tract other than a much higher percentage of active ingredient will be delivered and sticking to intestinal walls to stay in contact and penetrate the walls, unlike tablets which will be powder particles passing over the walls and some ingredient passing through the walls. Being able to stick and penetrate is the main difference here. It is also not a slow system it will be happening fast so you wont get a blocked gut or anything like that the goal is absorption and with absorption you have a time frame take too long and you will lose your time frame so it is fast and slippery. Thus blood levels will peak quickly and since more is absorbed levels will sustain longer (as shown with the pre workout test we did last week)

The main point of difference here compared to a tablet or powder is the tablet once broken into powder will have a particle size those particles will be large they will flow through the intestines and only some will come in contact with the intestinal walls, since the particle size is large not all of the particle will absorb or get a chance to absorb before being broken away from the wall. Having the ability to stick to the surface wall with a SEDDS formula is the first point of difference, then having a much smaller particle size will increase the absorption and lastly having excipients which in a way help open up pores and break through the aqueous barrier and penetrate the surface walls harder to help deliver the ingredients to the blood stream.

For poorly soluble ingredients or drugs like resveratrol 500-800% increase for highly soluble ingredients or drugs like BCAA's 1000-1500% increase + the system also has the ability for absorption in the mouth by holding it for 1-2 minutes and also when passing through the esophagus.....basically any biological membrane surface can be used as an absorption point.
 

lkt004

Member
So you're saying it hasn't been tested to determine if it's actually more effective than taking a tablet?

If i were to make a claim my drug was absorbed 1000* more efficiently than others, i would have to prove it, this is my issue.

You can make an essentially identical sedd and it may not conform to your estimations, this is the issue at hand, if the industry was properly regulated, you wouldn't be able to make such claims based on estimations.

Unless you know the exact increase in absorption, i would not be publishing it.
 
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