I've been running around 10 to 15k a week lately. Love it.
Previously I had all sorts of problems with my IT band leading to runners knee. I found that using a foam roller and "the stick" has helped and I also started wearing nike free run 2's instead of the more cushioned asics I used to wear.
The free runs initially gave me too much road feedback, so my shins were a bit sore, but that passed.
I've also gone to a chiro who did adjustments on my back and hips, which seemed to help (although maybe that was a placebo effect).
Another hint is don't try to go all out and kill yourself on your first run back
